Shiva Houjeghani; Sorayya Kheirouri; Esmaeil Faraji; Mohammad Asghari Jafarabadi; Masoumeh Jabbari
Volume 20, Issue 3 , 2018, Pages 1-8
Abstract
Background: Oxidative stress in the pathogenesis of diabetes is of great prominence and that Carnosine is a natural antioxidant. Objectives: This study was aimed to investigate the effect of Carnosine supplementation on different oxidative stress biomarkers in patients with type 2 diabetes mellitus (T2DM). ...
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Background: Oxidative stress in the pathogenesis of diabetes is of great prominence and that Carnosine is a natural antioxidant. Objectives: This study was aimed to investigate the effect of Carnosine supplementation on different oxidative stress biomarkers in patients with type 2 diabetes mellitus (T2DM). Methods: In this randomized, double-blind placebo-controlled trial, 54 patients with T2DM were employed from Tabriz Sheikhor- raees polyclinic and Imam-Reza Hospital endocrine center, and assigned to either the intervention group (n = 27) to receive two cap- sules of Carnosine 500 mg each or the control group (n = 27) to take two capsules of crystalline microcellulose for 12 weeks. Serumlevels of fasting blood sugar (FBS), malondialdehyde (MDA), protein carbonyl (PC) and erythrocytes content of catalase (CAT), and superoxide dismutase (SOD) were assessed before and after the supplementation. Results: A total of 44 patients completed the study. Anthropometric indices and energy intake did not show a significant changein both studied groups. Improved catalase level and decreased serum levels of fasting blood sugar, malondialdehyde and protein carbonyl occurred in the carnosine group compared to the placebo group after adjusting for baseline values and confounders (P < 0.05). Between-group differences were not significant for other variables at the end of the research. In the placebo group, none of the studied biomarkers were altered significantly. Conclusions: Our findings divulge the beneficial effects of carnosine supplementation in improving the antioxidant status and attenuating some of the oxidative stress biomarkers in patients with T2DM making it a useful adjunct therapy.
